Showing posts with label diet. Show all posts
Showing posts with label diet. Show all posts

Sunday, June 23, 2024

When it's hot, drink more water; here are ways to get that done

Photo illustration from CDC
Kentucky Health News


Staying hydrated is essential to maintaining health, especially during summer months. Aside from preventing dehydration, the Centers for Disease Control and Prevention reports that water helps your body maintain normal temperature, facilitate joint movement and protection, protect sensitive tissues like your spinal cord and remove waste through sweat, urination and bowel movements.

Here are tips for staying hydrated this summer, and there are more available at cdc.gov/healthy-weight-growth/water-healthy-drinks/index.html.

Upgrade your water bottle. Buying a reusable water bottle to refill throughout the day can help ensure you drink enough water. Freezing pre-filled plastic water bottles can be a great way to make sure you have access to cold water throughout the day, especially if you plan to spend an extended amount of time outside. Consider buying a flavor-infusing water bottle to add fruit flavors to your water if you dislike the taste of plain water.

Cut back on other drinks. Substitute water for sugary drinks like sodas or teas when you feel thirsty and consume alcohol, caffeine and energy drinks in moderation. Sports drinks can be a good way to restore electrolytes after prolonged periods of sweating and heavy physical activity, but avoid consuming them outside of regenerating electrolytes. Remember that choosing to drink water as often as possible will help keep you hydrated.

Make water part of your meals. Water is usually a drink option at restaurants, so choose to order water when given the opportunity. If you plan to host dinners or parties this summer, serve water and water-based drinks with your meals. Serve recipes with fruits and vegetables that contain water, like cucumbers and tomatoes. Whether you plan to eat indoors or outside, consider keeping a pitcher of ice water on the table during meals so guests can refill their glasses as they need to. Add a wedge of lime or lemon to your water.

Some other beverages can be part of healthy eating patterns: Plain coffee or teas, sparkling water, seltzers, and flavored waters are low-calorie choices. Low-fat or fat-free milk; unsweetened, fortified milk alternatives; and 100% fruit or vegetable juice contain important nutrients. Enjoy these drinks within recommended calorie limits. Milk contains important nutrients such as calcium, potassium, and vitamin D.

What about other beverages? Here's what the CDC says:
  • Sugary drinks: Regular sodas, fruit drinks, sports drinks, energy drinks, sweetened waters, and sweetened coffee and tea contain calories but little nutritional value. Learn how to Rethink Your Drink.
  • Alcoholic drinks: If you choose to drink alcohol, do so in moderation.
  • Caffeinated drinks: Moderate caffeine consumption (up to 400 mg per day) can be a part of a healthy diet. That's about 3 to 5 cups of plain coffee.
  • Drinks with sugar alternatives: Drinks that are labeled "sugar-free" or "diet" likely contain high-intensity sweeteners, such as sucralose, aspartame, or saccharine. These sweeteners may reduce caloric intake in the short term. However, there are many questions about the sweeteners' effectiveness for long-term weight management.
  • Energy drinks: In addition to added sugar, these products may also contain large amounts of caffeine and other legal stimulants. Concerns have been raised about the potential health risks of these products, especially for young people. 
Regularly consuming water during the summer will help you stay hydrated and healthy. Find more resources about water and hydration at nutrition.gov/topics/basic-nutrition/water-hydration-and-health and heart.org/en/healthy-living/fitness/fitness-basics/staying-hydrated-staying-healthy.

Wednesday, June 19, 2024

Curious about new, popular weight-loss drugs? Here's a lowdown

Axios Visuals map adapted by Ky. Health News; click to enlarge
Editor's note: At the end of 2023 Kentucky led the nation in the percentage of state residents, 2.1%, who had received the new class of diabetes and weight-loss drugs.

By Katelyn Jetelina
Your Local Epidemiologist

You’ve probably heard of Ozempic by now. It is everywhere. Sales are up more than 300% and research studies are coming out like a firehose, but future population-level implications are unknown. Here, we catch you up on the science and what it may mean for you.

Ozempic (one brand name for the substance semaglutide) is one of many medications under the umbrella of “GLP-1 receptor agonists.” Others are Trulicity (dulaglutide), Wegovy (semaglutide) and Mounjaro (tirzepatide).

GLP stands for glucagon-like peptide 1. GLP-1 is a hormone produced in the intestinal system and released when you eat food. It is a natural signal saying you have eaten enough food. Naturally occurring GLP-1 comes and goes in a few minutes.

These medications mimic this natural process but for longer. Ozempic, for example, stays in our system for an entire week. It also slows down gastric emptying, thereby slowing down digestion.

How effective are these drugs? Very. The original clinical trials that supported initial FDA approval for patients with diabetes blew expectations out of the water. It improved:
  • Blood sugar control (A1c reduction)
  • Weight loss (average 15 pounds)
  • Unexpected positives, like reduced kidney disease (24% less likely to experience kidney failure and death due to kidney complications)
Since the first clinical trials, studies have tested its use in non-diabetic individuals, and its is effective in weight loss. A meta-analysis of eight studies found a significant decrease (about 10% of body weight). None saw an increase. Also, it has protective effects on the heart, such as reduced blood pressure and triglycerides.
 
What happens if you stop taking it? Unfortunately, weight (and other outcomes) rebound. As shown below, after the original clinical trial (68 weeks), people who stopped taking it regained their weight.

The use of GLP-1’s as a motivating tool for sustained change has been less studied. Will these be lifetime drugs like other medications (e.g., statin drugs for heart disease) or a tool to titer up or down in times of need? This is a big unanswered question.

While obesity often involves an energy imbalance where calories consumed exceed those expended, it’s influenced by genetics, socioeconomic status, environmental factors, and mental health. These factors contribute to a complex web of challenges that may extend beyond individual choices alone.

What about kids? Ozempic isn’t officially approved by the FDA for children (but can be used off-label), but Wegovy is approved. In 2023 alone, about 31,000 children aged 12 to 17 and 162,000 aged 18 to 25 used these medications.

A recent meta-analysis found treatments led to modest reductions in body weight and improved glycemic control in children with insulin resistance.

Ozempic babies? The term refers to a recent phenomenon where women are reporting unplanned pregnancies. This has sparked discussions on social media and in the medical community about the potential impact of these drugs on fertility. Why could this be happening? Two hypothesized pathways:
  • 1. These drugs delay gastric emptying, which can impact the effectiveness of oral birth control by slowing down the rate of absorption
  • 2. Weight loss enhances fertility, making it easier for women to become pregnant. This is particularly true for women with Polycystic Ovarian Syndrome, in which weight loss is known to boost fertility significantly.
However, it’s recommended to stop the medication two months before trying to get pregnant (see more below).
 
Datawrapper graph by YLE; data from Ghusn et al., JAMA
Are there downsides to the meds?
Like any medication, there are side effects and risks, some known and some theoretical, and many with mixed study results. Individuals must weigh the risks of obesity with the small but meaningful risks of the medication.
 
Many people experience side effects, particularly nausea and diarrhea. A recent analysis from an insurance agency found that 6 in 10 people who start the drugs quit before they see benefits because of side effects. These tend to go away after a few weeks, but they can substantially impact the quality of life until then.

Muscle loss: Most (60-75%) weight loss is from fat, but some is from non-fat, including muscle. This could lead to a rare condition called sarcopenia—loss of muscle mass and strength where you can’t do much because you’re physically weak. Research is mixed, though, on how often this happens, and it may be minimal when combined with exercise and adequate protein intake.
 
Increased risk of thyroid cancer. A small French case-control study found an elevated risk of thyroid cancers (58% elevated relative risk) and medullary thyroid cancer (78% elevated relative risk) after GLP-1’s. However, another study in Scandinavia with more than 400,000 people found no risk of thyroid cancer after 3 years. Regardless, the potential increase in absolute risk is very small.

Mental health. There is a big debate on what is happening in the brain. GLP-1 is not only produced in the gut but in the brain as well. Some evidence has correlated the usage of GLP-1 medications with suicidal ideation. However, recent evaluations by regulatory agencies found no substantial evidence after extensive review. Some studies have even suggested a potential decrease in the likelihood of anxiety and depression.

Eating disorders. It is a growing concern that GLP-1s may increase the risk of disordered eating, particularly among those who are high-risk (e.g., prior history of eating disorders).
 
Pregnancy. Pre-clinical trials on rats found GLP-1s are more likely to have offspring with birth deformities, so it’s not recommended to take during pregnancy.

While these new drugs have a strong safety profile based on available data, human studies are only about 5 years old. This means the long-term effects are not yet fully understood. However, we do have data from drugs in the same class that started testing in 2006, showing a consistent safety profile. Continued monitoring and research are essential to determine whether theoretical risks are real in light of new data.

This means decisions today must be made based on what is available and in the context of individual risk factors. For example, if you have a history of eating disorders, the risks of taking the medication may outweigh the benefits.

What does the future look like? After a century of fad diets and weight loss gimmicks, people are tired: some from fighting stigma and others from trying to lose weight unsuccessfully. These medications have proven to work, and the market shows it: GLP-1 prescriptions have increased by over 300% since 2020. A recent poll indicates that nearly half of adults express interest. But there’s no sugarcoating it: It’s expensive, about $1,000 per month without insurance. The price should decrease dramatically in about 8 years once the patent expires and the generic version comes to market.

On a population level, these drugs will likely have widespread impacts, just like the iPhone, which can be good or bad, depending on who you ask. Given the massive impact obesity has had on health in the past two decades, this could be extraordinary for lifespan and quality of life. It could also have ripple effects on the fast-food industry and save millions of dollars in health care costs.

But it could further widen health disparities, given the cost, and hurt body positivity, losing much ground gained. We also cannot ignore that these drugs benefit a billion-dollar pharmaceutical industry when underlying societal causes should be addressed for prevention. And, the fact there are numerous other benefits to a healthy lifestyle.
Bottom line

GLP-1 drugs offer much-needed hope to individuals, and a flood of studies show their effectiveness. However, there are both demonstrated and theoretical risks to consider. Regardless, obesity deserves compassion, and perhaps 21st-century tools can help foster a supportive environment that promotes lasting progress.

Monday, May 13, 2024

Food-as-medicine effort at UK gets a boost from new endowment

Alison Gustafson (UK photo by Sabrina Hounshell)
By Christopher Carney

One of the first two Gatton Foundation endowed professors at the University of Kentucky is Alison Gustafson, who directs the Food as Health Alliance. The endowment, from a $100 million gift by the late Bill Gatton, will provide funds to developing and expanding food-as-medicine programs across the state.

The money will help build capacity for health-care providers to get key services for diet-sensitive patients who are at risk of food insecurity. Gustafson is also developing and expanding community partnerships, offering approved food-as-medicine programs to those who qualify, and building a referral and network hub that will give patients a connection to services regardless of location. 

“Our team will be conducting expansion efforts for screening and referral, capacity building among community groups, outreach, UK Cooperative Extension training and research projects to better serve Kentuckians experiencing food insecurity,” Gustafson said. 

Gustafson is a professor in the Department of Dietetics and Human Nutrition in the Martin-Gatton College of Agriculture, Food and Environment and the College of Nursing. Under terms of the gift from the Bill Gatton Foundation, distinguished faculty get resources to continue meaningful research, extension and instructional programs related to advancing UK’s land-grant mission. 

The Food as Health Alliance was launched at UK in 2023 to boost health and well-being in the state through the combined application of agricultural, medical, and nutritional resources. Gustafson works to bring together clinical and community research to address the dual challenges of food insecurity and diet-related chronic diseases that many Kentuckians face.

Gustafson earned a doctoral degree in nutrition epidemiology from the University of North Carolina and a master's degree in public health from Boston University. As a master's student, she spent a year in Zimbabwe working with AIDS orphans. She has worked in local and state health departments, focusing on community health for disadvantaged populations. 

The other Gatton endowed chair, Tiffany Messer, will get support for student training and success, water-quality needs assessments, and low-cost water-quality treatment options. She is an associate professor of biosystems and agricultural engineering in the college.

Tuesday, May 7, 2024

Stomach cancer: How to recognize the signs and reduce your risk

Illustration by peterschreiber.media via iStock/Getty Images Plus
By Dr. Joseph Kim
University of Kentucky

While stomach cancer was in the headlines not long ago with the sudden death of musician Toby Keith, the diagnosis is relatively rare. Stomach cancer now accounts for 1.4% of new cancer cases in the U.S., down from nearly 10% from 30 years ago.

With an average age at diagnosis of 68, stomach cancer is more common among older individuals. But it can happen to anyone, so it’s important to understand its symptoms, risk factors and steps you can take to lower your risk.

What are the signs and symptoms of stomach cancer? Early stage stomach cancer often has no symptoms. As the cancer progresses, patients may experience abdominal pain or discomfort, feeling bloated or full after eating small amounts, nausea or vomiting, unexplained weight loss, blood in the stool and difficulty swallowing.

What causes stomach cancer? There are not always clear risk factors for developing stomach cancer, but some factors tend to be associated with the onset of the disease. These include:
  • Heavy consumption of smoked, salted and processed meats
  • A diet low in fruits, vegetables and fiber rich foods
  • Smoking tobacco
  • Being overweight or obese
Other risk factors include gastroesophageal reflux disease (GERD), a family history of stomach cancer, Epstein-Barr virus and H. pylori bacterial infection.

What can I do to reduce my risk? While there is no guaranteed way to prevent stomach cancer, you can lower your risk by:
  • Eating a balanced diet with plenty of fruits, vegetables and whole grains. Limit processed meats and smoked or salty foods.
  • Maintaining a healthy weight through diet and exercise
  • Quitting smoking and limiting alcohol consumption
Can I get screened for stomach cancer? Routine screening isn't currently recommended for everyone. But if you have certain risk factors, like H. pylori infection or a family history of stomach cancer, talk to your doctor about screening options like upper endoscopy or blood tests.

While treatments have progressed in recent years, the five-year relative survival rate for stomach cancer is 35.7%. Early detection can make all the difference for better treatment outcomes, so don't hesitate to reach out to your health care provider if you experience any symptoms or have risk factors that warrant screening.

Joseph Kim, M.D., is a surgeon at the UK Markey Cancer Center.

Friday, March 22, 2024

UK diabetes research featured in group's annual research report

Brittany Smalls, Ph.D., is at upper right.
By Hilary Smith
University of Kentucky

One of the cover stories in the annual reserach report from the American Diabetes Association is about a University of Kentucky researcher devoted to helping rural Kentuckians — specifically in Appalachia — better manage their diabetes.

highlighting investments in advancing diabetes research and clinical practice. ADA research grants focus on innovative projects with high impact and help researchers establish collaborative networks to move their innovations into the hands of people living with diabetes.

Brittany Smalls an associate professor and the Dr. Claire Louise Caudill Professor in Family Medicine in the UK’s Department of Family and Community Medicine. Her futire work in Appalachia will look at intergenerational households, where large extended families often live together in the same home or throughout shared pieces of land. These families share everything from living spaces, meals, household chores, caregiving and more.

Such househodls are common in Appalachia, and so is a disproportionately high risk for Type 2 diabetes. The prevalence of Type 2 diabetes reaches 23% in Kentucky’s most rural counties, more than twice the state average.

Throughout her career of helping older adults with type 2 diabetes, Smalls quickly noticed that the adult children and grandchildren of those she worked with could also benefit from her research.

Thanks to an award from the ADA, Smalls will expand her focus from older adults with type 2 diabetes to entire families living with or who are at risk for the disease.

“By tapping into tight-knit family units, we can start to shift how people think about their health and how they think about each other,” Smalls said.

The cover story from the ADA’s report details Smalls’ work resulting from the award:

“She is piloting a health intervention that leverages social support within family units to promote nutrition and physical activity, which are key to mitigating obesity and type 2 diabetes. Each participating family will receive a tailored six-month lifestyle plan. 

“Only one adult needs a type 2 diabetes diagnosis for a household to be eligible, and a dietitian will engage them in medical nutrition therapy based on available foods. Participating families will receive ADA-backed recommendations for physical activity based on family members’ physical ability.”

Monday, February 19, 2024

Heart Association gives UK grant to spur 'food as medicine' effort

By Grace Sowards
University of Kentucky

The Food as Health Alliance at the University of Kentucky has received a grant from the American Heart Association. UK is among the first recipients of AHA’s Health Care by Food Initiative awards.

Alison Gustafson (UK photo by Sabrina Hounshell)
FAHA director Alison Gustafson is a faculty member in the University of Kentucky Martin-Gatton College of Agriculture, Food and Environment. She will use the $386,000 grant over the next year and a half to see how a user-centered design program can improve screening, referral enrollment and engagement in food-as-medicine programs for adults with food insecurity and high blood pressure or other diet-sensitive chronic diseases.

This grant also involves UK HealthCare and Appalachian Regional Healthcare, with key partnerships from Instacart, Kroger Health with Soda Health, Mom’s Meals and Food City.

“We are looking forward to working with our partners across the state to improve screening, referral and enrollment practices to improve patient outcomes,” said Gustafson, a professor in UK's Department of Dietetics and Human Nutrition.  She has partnered with Instacart, Mom’s Meals and Food City on current pilot projects across Kentucky to help develop the infrastructure for patients receiving food-as-medicine programs.

The grant team is developing a referral hub for health-related social needs with key organizations in Kentucky. FAHA is bringing together diverse health-care, managed-care, non-profit and industry collaborators to facilitate screening, referral and enrollment to identify the most suitable and effective model(s) in the short term, while considering design for long-term sustainability.

FAHA seeks to bring together clinical and community research spanning across agriculture, food, health care and nutrition to address food insecurity and diet-related chronic disease. Researchers, community partners, food commodity producers, health care partners and students will explore innovative strategies to improve patient clinical outcomes and Kentuckians’ health.

“This award is an acknowledgment of the tremendous work the Food as Health Alliance has already been doing to address inequities related to food insecurity and chronic disease across Kentucky,” said Carolyn Lauckner, assistant professor in the Department of Behavioral Science at the UK College of Medicine and co-principal investigator on the grant with Gustafson.

“The grant demonstrates an investment in our efforts to use food as medicine to improve individuals’ health by targeting the link between food insecurity and cardiovascular disease,” Lauckner said. “I am thrilled to be working with this outstanding group of scholars and practitioners committed to using innovative, community-engaged research methods to improve the health of all Kentuckians.”

For more information on FAHA, visit https://foodashealthalliance.ca.uky.edu. For more information about the American Heart Association’s Health Care by Food Initiative, visit https://healthcarexfood.org.

Friday, January 5, 2024

'SMART' ways to make those New Year’s resolutions stick

SMART goals concept
(Wikipedia graphic)
By Shorus Minella
University of Kentucky

If you’re looking for ways to make those New Year’s resolutions stick, try finding something you are really motivated to do. You are more likely to want to work toward a goal if you enjoy the activity. 

For example, if you want to start exercising but hate exercise equipment at the gym, find a dance or aerobic class instead.

After you’ve identified something you want to work towards, be realistic and set a specific goal. 

Instead of a broad goal like “I want to eat healthy,” instead, try “I want to eat two cups of vegetables every day.” You’re more likely to accomplish and stick to a specific goal.

Following the SMART goals concept is a great guide to setting and sticking to goals. Here’s what to keep in mind when making your goals:
 
Specific – Giving yourself a very specific goal makes it easier to achieve. For example, instead of setting a goal to lose weight, aim for a specific number, such as five pounds. When you reach that goal, aim for another five pounds.
Measurable – Set yourself up for success by tracking your progress. Seeing how far you’ve come is an excellent motivator!
Achievable – If you’ve never run a step in your life, vowing to run a marathon might be a difficult goal to stick to. Start small by running around the block, then a mile, then try signing up for a community 5K.
Relevant – Your goals should be in line with your values and passions. You’re more likely to achieve your goal if you are enjoying it!
Time-Based – Give yourself a realistic time frame to complete your goal.

Most importantly, give yourself grace during your journey. Celebrate your successes but don’t get discouraged by any setbacks. Talk to your doctor or check in with the local health department for resources and programs to help you meet your goals.

Shorus Minella is a dietitian and patient education coordinator at UK HealthCare’s Gill Heart & Vascular Institute.

Thursday, October 5, 2023

Nonalcoholic fatty liver disease now common in children; experts at UK and elsewhere say causes include diet and lack of exercise

Dr. Samir Softic (Washington Post photo by Drea Cornejo)
Kentucky Health News

For uncertain reasons, nonalcoholic fatty liver disease has become more common in American children, especially in Kentucky, and “It’s the worst disease you’ve never heard of,” said Samir Softic, a pediatric gastroenterologist at the University of Kentucky Children’s Hospital, who specializes in the disease.

Softic is a main focus of a long story in The Washington Post about the disease, which is estimated to affect 5 to 10 percent of U.S. children, "making it about as common as asthma, Post reporter Ariana Eunjung Cha writes. A video with the story says Kentucky's rate "is believed to be among the highest."

Cha reports, "The crisis is especially acute in swatches of the Southeast, where rates of pediatric obesity are highest," including Appalachian Kentucky. "But obesity is only part of the puzzle. Scientists have been surprised to find that not all kids with obesity have fatty liver, and not all kids who have fatty liver disease struggle with weight."

Softic runs UK's pediatric fatty liver clinic, which this spring was "often fully booked two to six months in advance," Cha reports. The disease often has few symptoms until it becomes serious, at which point it can cause weakness, severe tiredness, weight loss, yellowing of the skin or eyes, spiderlike blood vessels on the skin and long-lasting itching," says Johns Hopkins Medicine.

"For Softic, the fatty liver crisis is as much about policy as science. He has collected a stack of letters from insurers refusing to cover some patients’ treatment with a new generation of weight-loss drugs known as semaglutides, sold under brand names including Ozempic and Wegovy. The companies say the medications are not yet proven to help with fatty liver.

"While Softic believes that fundamental changes in how we eat and exercise are needed in the long term, he said lives could be saved in the short term if these drugs were widely and cheaply available. He’s lobbying state and federal regulators to help pay for the treatments — which can cost upwards of $1,300 a month — for patients younger than 18, who arguably have the most to gain because they have more of their lives ahead of them.

Washington Post graphic frrom Trilliant Health analysis of claims
"Liver transplants in children diagnosed with fatty liver disease remain rare, but Softic recently referred a 6-year-old for a transplant evaluation. There has been a clear rise in transplants for fatty liver in people in their 20s and 30s, meaning if he can’t help his pediatric patients now, they may soon face a transplant."

Softic told Cha the disease “goes unnoticed and unrecognized, and over time it catches up. For a good number of these young transplant patients, the disease process started in childhood,” he said. “On so many levels, we are not prepared to deal with this disease in children.”

A seven-minute video with the story includes the case of Sydney Woods, a Kentucky 15-year-old with fatty liver disease who improved her liver function by "cutting out soda and making other changes to her diet . . . but it's not as easy for most families to buy less procesed food." That's especially true in rural areas, said her mother, Angela Woods, a physician's assistant.

Softic says in the video, "Eating healthy requires time, it requires money, and not everyone has those resources."

Cha reports, "Many doctors believe that our modern lifestyle — diet, the increase in sedentary activities related to technology and environmental exposures — is to blame. One of the liver’s jobs is to filter toxins, and when something in the body is out of balance, the organ can become damaged and fail. Some pediatric experts theorize there’s a mismatch between our genetics and the highly processed and sugary foods that have come to dominate childhood diets," including some types of infant formula. The video says 67% of children's diets consist of ultra-processed foods.

"It's a major problem, and it's been exacerbated by diet and inactivity," Simon Fisher, director of UK's Barnstable Brown Diabetes Center, says in the video.

Cha reports, "The escalation of pediatric fatty liver cases has unfolded in tandem with the presence among the young of other conditions once viewed as almost exclusively adult diseases: high blood pressure, high cholesterol, diabetes, even gallstones."

Tuesday, July 25, 2023

Weight-loss drugs carry high prices, many questions for seniors

By Judith Graham
KFF Health News

Corlee Morris has dieted throughout her adult life.

After her weight began climbing in high school, she spent years losing 50 or 100 pounds then gaining it back. Morris, 78, was at her heaviest in her mid-40s, standing 5 feet 10½ inches and weighing 310 pounds. The Pittsburgh resident has had diabetes for more than 40 years.

Photo by Mario Tama, Getty Images
Managing her weight was a losing battle until Morris’ doctor prescribed a Type 2 diabetes medication, Ozempic, four months ago. It’s one in a new category of medications changing how ordinary people as well as medical experts think about obesity, a condition that affects nearly 4 in 10 people 60 and older.

The drugs include Ozempic’s sister medication, Wegovy, a weight loss drug with identical ingredients, which the FDA approved in 2021, and Mounjaro, approved as a diabetes treatment in 2022. (Ozempic was approved for diabetes in 2017.) Several other drugs are in development.

The medications reduce feelings of hunger, generate a sensation of fullness, and have been shown to help people lose an average of 15% or more of their weight.

“It takes your appetite right away. I wasn’t hungry at all and I lost weight like mad,” said Morris, who has shed 40 pounds.

But how these medications will affect older adults in the long run isn’t well understood. (Patients need to remain on the drugs permanently or risk regaining the weight they’ve lost.)

Will they help prevent cardiovascular disease and other chronic illnesses in obese older adults? Will they reduce rates of disability and improve people’s ability to move and manage daily tasks? Will they enhance people’s lives and alleviate symptoms associated with obesity-related chronic illnesses?

Unfortunately, clinical trials of the medications haven’t included significant numbers of people ages 65 and older, leaving gaps in the available data.

While the drugs appear to be safe — the most common side effects are nausea, diarrhea, vomiting, constipation, and stomach pain — “they’ve only been on the market for a few years and caution is still needed,” said Mitchell Lazar, founding director of the Institute for Diabetes, Obesity and Metabolism at the University of Pennsylvania.

Given these uncertainties, how are experts approaching the use of the new obesity medications in older people? As might be expected, opinions and practices vary. But several themes emerged in nearly two dozen interviews.

Limited access

The first was frustration with limited access to the drugs. Because Medicare doesn’t cover weight loss medications and they can cost more than $10,000 a year, seniors’ ability to get the new drugs is restricted.

There is an exception: Medicare will cover Ozempic and Mounjaro if an older adult has diabetes, because the insurance program pays for diabetes therapies.

“We need Medicare to cover these drugs,” said Shauna Matilda Assadzandi, a geriatrician at the University of Pittsburgh who cares for Morris. Recently, she said, she tried to persuade a Medicare Advantage plan representative to authorize Wegovy for a patient with high blood pressure and cholesterol who was gaining weight rapidly.

“I’m just waiting for this patient’s blood sugar to rise to a level where diabetes can be diagnosed. Wouldn’t it make sense to intervene now?” she remembered saying. The representative’s answer: “No. We have to follow the rules.”

Seeking to change that, a bipartisan group of lawmakers introduced the Treat and Reduce Obesity Act, which would require Medicare to cover weight loss drugs. But the proposal has languished amid concerns over enormous potential costs for Medicare.

If all beneficiaries with an obesity diagnosis took this new class of medications, known as semaglutide drugs, annual costs would top $13.5 billion, according to a recent analysis in The New England Journal of Medicine. If all older obese adults on Medicare — a significantly larger population — took them, the cost would exceed the total spent on Medicare’s Part D drug program, which was $145 billion in 2019.

Laurie Rich, 63, of Canton, Mass., was caught off guard by Medicare’s policies, which have applied to her since she qualified for Social Security disability insurance in December. Before that, Rich took Wegovy and another weight loss medication — both covered by private insurance — and she’d lost nearly 42 pounds. Now, Rich can’t get Wegovy and she’s regained 14 pounds.

“I haven’t changed my eating. The only thing that’s different is that some signal in my brain is telling me I’m hungry all the time,” Rich told me. “I feel horrible.” She knows that if she gains more weight, her care will cost much more.

Who should take these drugs?

While acknowledging difficult policy decisions that lie ahead, experts voiced considerable agreement on which older adults should take these drugs.

Generally, the medications are recommended for people with a body mass index over 30 (the World Health Organization’s definition of obesity) and those with a BMI of 27 or above and at least one obesity-related condition, such as diabetes, high blood pressure, or high cholesterol. There are no guidelines for their use in people 65 and older. (BMI is calculated based on a person’s weight and height.)

But those recommendations are problematic because BMI can under- or overestimate older adults’ body fat, the most problematic feature of obesity, noted Rodolfo Galindo, director of the Comprehensive Diabetes Center at the University of Miami.

Dennis Kerrigan, director of weight management at Henry Ford Health in Michigan, a system with five hospitals, suggests physicians also examine waist circumference in older patients because abdominal fat puts them at higher risk than fat carried in the hips or buttocks. (For men, a waist over 40 inches is of concern; for women, 35 is the threshold.)

Fatima Stanford, an obesity medicine scientist at Massachusetts General Hospital, said the new drugs are “best suited for older patients who have clinical evidence of obesity,” such as elevated cholesterol or blood sugar, and people with serious obesity-related conditions such as osteoarthritis or heart disease.

Since going on Mounjaro three months ago, Muriel Branch, 73, of Perryville, Arkansas, has lost 40 pounds and stopped taking three medications as her health has improved. “I feel real good about myself,” she told me.

When adults with obesity lose weight, their risk of dying is reduced by up to 15%, according to Dinesh Edem, Branch’s doctor and the director of the medical weight management program at the University of Arkansas for Medical Sciences.

Still, weight loss alone should not be recommended to older adults, because it entails the loss of muscle mass as well as fat, experts agree. And with aging, the shrinkage of muscle mass that starts earlier in life accelerates, contributing to falls, weakness, the loss of functioning, and the onset of frailty.

Between ages 60 and 70, about 12% of muscle mass falls away, researchers estimate; after 80, it reaches 30%.

To preserve muscle mass, seniors losing weight should be prescribed physical activity — both aerobic exercise and strength training, experts agree.

Also, as older adults taking weight loss drugs eat less, “it’s critically important that their diet includes adequate protein and calcium to preserve bone and muscle mass,” said Anne Newman, director of the Center for Aging and Population Health at the University of Pittsburgh.

Ongoing monitoring of older adults having gastrointestinal side effects is needed to ensure they’re getting enough food and water, said Jamy Ard, co-director of Wake Forest Baptist Health’s Weight Management Center.

Generally, the goal for older adults should be to lose 1 to 2 pounds a week, with attention to diet and exercise accompanying medication management. That's important, said Sukhpreet Singh, system medical director at Henry Ford’s weight management program.

“My concern is, once we put patients on these obesity drugs, are we supporting lifestyle changes that will maintain their health? Medication alone won’t be sufficient,” Singh said. “We will still need to address behaviors.”

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

Sunday, May 7, 2023

UK's new Food as Health Alliance will look at ways to use food to improve patient outcomes and Kentucky's overall health

The University of Kentucky Food as Health Alliance celebrated its official launch April 27 with a $200,000 contribution from the Kentucky Association of Health Plans, the trade group of insurance companies operating in the state.

The alliance, formed by UK's College of Agriculture, Food and Environment, will work with clinical, community, academic and industry leaders to improve the state's programs that use diet and nutrition to improve patient outcomes and the overall health of Kentuckians.

The association's gift will fund four research pilot projects in urban and rural communities by the college's Department of Dietetics and Human Nutrition. The projects will work with partners to develop cost-effective and clinically meaningful food-delivery programs, such as prescriptions for groceries or medically tailored meals.

The projects will also measure clinical outcomes, along with impacts on health-care costs among food-insecure adults who are diagnosed with type 2 diabetes, gestational diabetes or heart disease.

One project will partner with Instacart, an online grocery-delivery service, to analyze the benefits of using food as medicine via prescriprions for groceries. It was noted in a White House announcement in March.

The alliance has produced 10 nutrition-focused cooking videos, made internal grants at UK, and developed plans for videos to train clinicians. Its director, Alison Gustafson, said in a news release, "I am so moved by the array of individuals and organizations across our state that are devoted to reducing food insecurity and improving the health of our residents."

Thursday, February 23, 2023

American Heart Month and Black History Month are the same month, and are related; Blacks are likelier to have heart disease

By Dr. Daniel Brunner

In February, we commemorate both American Heart Month and Black History Month, which presents an opportunity for us to raise awareness about cardiovascular health, remember the contributions of African Americans who helped shape the nation and reflect on the continued struggle to overcome disparities. As February ends, I urge everyone to commit to mind the teachings of American Heart Month and Black History Month throughout the year. That’s because a particular disparity that impacts the African American community is heart disease – the leading cause of death for African Americans and all adults across the U.S.

Daniel Brunner, M.D.
According to the Centers for Disease Control and Prevention, more than 20 million U.S. adults — approximately 7% of the U.S. population — have heart disease. The disparity lies in the fact that nearly 48% of African American women and 44% of African American men have some sort of heart disease. This is a lot higher than the 36% of white, non-Hispanic adults in the U.S. who have heart disease. In Kentucky, where heart disease is the commonwealth’s leading cause of death, 11.8% of the African American population has been diagnosed with a cardiovascular disease — higher than the national average of 9%.

While many factors contribute to their increased risk, what matters is that heart disease is killing Black Americans at a higher rate than any other group in the U.S., and the best way to fight this disparity is to successfully treat the risk factors.

Here is what people need to know:

Screening: Getting screened by a medical professional will help identify risk factors for heart disease early enough to treat it. Medical screening will identify if there are genetic risks or if factors such as weight, environment and habits are putting a person at higher risk of disease and death. Getting screened at least once a year is crucial for all adults.

Medication management: It’s not only important for people to take prescribed medication as directed for heart disease and other conditions that cause heart disease (such as diabetes, high cholesterol and high blood pressure), but is also important to communicate with a doctor to help manage conditions and adjust medication when required.

Staying active: Staying physically active reduces and helps manage weight. It may reverse early diabetes and cut cholesterol levels. It can even help control stress and hypertension. All it takes is 30 minutes a day, at least five days a week of exercise that is enjoyable, like walking, running, swimming, cycling, dancing, playing a sport or anything that gets the heart pumping.

Diet: It is extremely important to watch your diet to help maintain a healthy weight and heart. Certain ethnic food or diets and sugar-sweetened beverages are widely embraced in many communities. Some diets may be associated with a significantly increased risk of heart disease. With risk factors as high as they are, it is critical to be diligent with limiting foods that are rich in sugar, fat, calories and sodium.

Lifestyle choices: While it is not possible to change genes that are inherited, it is possible to make lifestyle changes that can influence heart health. Cutting smoking, getting six to eight hours of quality sleep at night and refraining from overeating could make a positive difference in heart health. Also important is cutting stress, since stress can increase hormones that elevate blood pressure. If stress continues long-term, it can lead to permanent hypertension, an irregular heart rhythm or a permanent heart condition.

Fighting back against heart disease doesn’t have to be undertaken alone. It’s obvious that people need their doctors to help, but in many cases, people can also turn to their health insurer for support. Many health plans offer special assistance in the form of case managers who work with patients and providers to determine a course of action that best serves a patient’s needs.

Accessing no-cost screenings, managing medication, and utilizing benefits designed to help members stay active or access diet programs are key to ensuring a healthy life. Reach out to your health plan to manage the thing that is most important – your health.

Daniel Brunner, M.D., is medical director for Anthem Blue Cross and Shield Medicaid in Kentucky. He is an emergency medicine physician based in Northern Kentucky.

Sunday, January 15, 2023

Dietitian says even 10% weight loss has health benefits; weight-loss drugs, diets and pediatric guidelines are in the news

American Heart Association photo
By Melissa Patrick
Kentucky Health News

As the end of January approaches and that New Year's resolution to lose weight may have already been forgotten, it's important to remember that if you are overweight, it's worth the effort to hang onto that resolution. Even losing up to 10 percent of your body weight can provide health benefits. 

Karen Klefot, registered dietitian and diabetes consultant at the Barnstable Brown Diabetes Center at the University of Kentucky, told Kentucky Health News that it's important for a person to set short-term goals when they are trying to lose weight and that even a 10% weight loss can improve blood pressure, sleep, diabetes, cholesterol and energy levels.  

"There is value in losing up to 10 percent of an individual's weight," Klefot said. "Oftentimes, we feel like we have to lose 50 pounds, but . . . that's a lot of weight, when really, honestly, you know, we can have those health benefits with it only being 10 percent."

Klefot offered several suggestions for getting started with a weight-loss plan, including keeping track of your daily exercise and daily food intake as a way to evaluate where some lifestyle changes can be made. 

"I think it's important to focus on things that are realistic and attainable, especially when it comes to weight loss," she said, later adding, "And I would say to focus on one to two pounds per week." 

For example, she said one easy lifestyle change is to trade sugar-sweetened beverages for water or to add more fiber-rich foods, fruits, vegetables and whole grains to the diet. And, she said, eat less fast food, which takes some planning ahead.    

Asked about the popular low-carbohydrate diets, Klefot stressed that it's important to not cut out carbohydrates completely because they are the main fuel source for our bodies. 

"We're not supposed to be depriving our body of carbs," she said. Also, "We need healthy fat and we need protein."

Further, she said it's important to limit sweet treats to "every now and then, but maybe not every single day." And if you have a strong sweet tooth, try adding more fruit to your diet. 

Klefot also noted that increasing your physical activity is important for weight loss, noting that the general recommendation is for a person to get 150 minutes of moderate-intensity aerobic activity a week. The Centers for Disease Control and Prevention adds two or more days of muscle-strengthening activities a week to that recommendaton. 

MyPlate.gov is the federal government's guide to healthy eating.
Recognizing that insurance does not always cover weight-loss efforts, Klefot encouraged people to look at reliable sources when it comes to seeking solutions, such as MyPlate.gov, the U.S. Department of Agriculture's guide to healthy eating. In addition, she encouraged yearly physicals and said local health departments often offers diabetes programs. 

"I wish more insurances would cover more appointments with a registered dietitian because I think more patients would be able to come," which would likely reduce both obesity and diabetes in Kentucky, Klefot said. 

Best diets in 2023

Each year U.S. News & World Report reviews a list of science-backed diets and ranks them. The diets are reviewed by a panel of leading medical and nutrition specialists in diabetes, heart health and weight loss. 

Of the 24 diets that were reviewed, the Mediterranean diet ranked first. This diet focuses on plant-based foods, like fruits and vegetables, while incorporating whole grains, beans, nuts, seafood, lean poultry and unsaturated fat from extra-virgin olive oil.

The DASH diet, which stands for dietary approaches to stop hypertension, or high blood pressure, tied for second place. It also emphasizes fruits, vegetables, whole grains, lean protein and low-fat dairy, which are high in blood pressure-lowering nutrients, like potassium, calcium, magnesium and fiber.

Also tied for second was the flexitarian diet, a semi-vegetarian diet that allows a person to be a vegetarian most of the time, but to still be able to enjoy meat on a special occasion. 

New weight-loss guidelines for children

For the first time in 15 years, the American Academy of Pediatrics has released new evidence-based recommendations for treating childhood obesity, with an emphasis on early and intensive treatment. 

The new guidelines stress that obesity is a chronic disease and should be treated as such. And while the guidelines continue to say that intensive behavioral therapy and lifestyle changes should be a first-line approach, for the first time AAP now recommends children 12 and older be considered for anti-obesity medications and those 13 and older with severe obesity be considered for weight-loss surgery. 

“There is no evidence that ‘watchful waiting’ or delayed treatment is appropriate for children with obesity,” Dr. Sandra Hassink, an author of the guideline and vice chair of the Clinical Practice Guideline Subcommittee on Obesity, said in an AAP news release.

NBC News reports that there are now four drugs approved for obesity treatment in teens starting at age 12: "Orlistat, Saxenda, Qsymia and Wegovy — and one, phentermine, for teens age 16 and older. Another drug, called setmelanotide (brand name Imcivree), has been approved for kids age 6 and older who have Barde-Biedl syndrome, a genetic disease that causes obesity."

In Kentucky, 39% of children were either overweight or obese in 2019-20, up from 37% in 2016-2017, according to the 2022 Kids Count Data Book. The State of Childhood Obesity report says that in 2020-2021, 25.5% of Kentucky's children were obese. 

New anti-obesity drugs are expensive

The Trust for America's Health latest annual report says four of every 10 Kentucky adults are obese and 72.3% are either obese or overweight, ranking the state third in the nation.

New drug treatments for obesity are working, but they are expensive and are not always covered by health insurance, Lesley Stahl reported Jan. 1 on CBS's "60 Minutes." 

One of those drugs is semaglutide, marketed under the brand Ozempic for Type 2 diabetes and Wegovy, in higher doses, for weight loss. CBS reports Ozempic was first approved by the Food and Drug Administration as a type 2 diabetes medication in 2017. Wegovy was approved by the FDA as a chronic weight management treatment in 2021.

In support of these medications, Dr. Fatima Cody Stanford, an obesity doctor at Massachusetts General Hospital and associate professor at Harvard Medical School, told Stahl that the common beliefs about obesity are all wrong. It's not willpower, she said, "It's a brain disease. And the brain tells us how much to eat and how much to store." Further, she said, "The number one cause of obesity is genetics." 

Doctors are frustrated that there are drugs that works for obesity, but insurance companies won't cover them. 

"We are frustrated every single day when we see patients who desperately need to lose weight to reduce diabetes, reduce the hypertension, stroke, heart disease, and we can't give them this fabulous, robust medication that is very effective and safe. And we can't give it to them because insurance won't cover it," Dr. Caroline Apovian, co-director of the Weight Management and Wellness Center at Brigham and Women's Hospital in Boston, told Stahl. 

In Kentucky, Ozempic and Wegovy are not covered by Medicaid for weight loss. Stahl reported that  Rhode Island officials have decided that health insurance for their state employees will cover the entire class of anti-obesity drugs.

NBC News reports that experts are confident that the FDA will likely approve Eli Lilly & Co.'s drug tirzepatide for weight loss in 2023, but it also will be expensive and there is little indication that insurers will widely cover it. 

Lilly declined to comment on the new drug's cost, but NBC reports, "Outside experts said it is possible the drugmaker could price it similarly to Wegovy, which carries a list price of around $1,500 for a month’s supply, and Saxenda, which costs about $1,350 for a month’s supply."

Tuesday, June 21, 2022

Your brain needs proper diet and exercise, too; it's something to remember in June, Brain and Alzheimer's Awareness Month

Photo illustration by Daniel de la Hoz, iStock/Getty Images Plus
By Dr. Greg Jicha
University of Kentucky

Healthy brain aging is a concern for all of us. June is recognized as Brain and Alzheimer’s Awareness Month. It’s normal to struggle with small things such as recalling names — and we all experience some slowing of the thought processes with advanced age — but everyone hopes to avoid serious cognitive impairment.

Some cognitive difficulties, such as Alzheimer’s disease, have underlying pathological causes that we are still working to understand. However, we know that brains can also lose function simply through poor physical, mental and social health. Many of the causes of cognitive decline are preventable.

Just as we create exercise regimens for the body, we should create a routine for brain health.

As a general rule, what is good for heart health is good for brain health. Getting regular exercise, eating well and maintaining a healthy weight all promote a healthy brain.

People of all ages, particularly seniors, benefit from leaving the house, engaging in learning activities and having an active social life. It is important to commit to a schedule that encourages all of these healthy brain aging activities.

Summer, in many ways, is an ideal time to set up a routine for healthy brain aging. Warm weather offers the opportunity to get physical exercise through gardening and walking. Many community organizations offer summer classes in dance, photography, art, music and other hobbies.

Summer also is the season of farmers markets and fresh produce. Fresh fruits and vegetables contain compounds called plant polyphenols. These compounds, which help plants fight off disease, have been observed in animal models to extend lifespan by promoting general cellular health. Blackberries, raspberries, blueberries and red wine are all good sources of polyphenols.

Anyone interested in healthy brain aging also can practice “neurobics.” These “aerobics for the brain” are activities that can be thrown into the daily schedule on a whim. Examples include taking a different route home, shopping at a different grocery store, or purposely driving or walking through an unfamiliar neighborhood. These simple activities activate the problem-solving areas of the brain as the person navigates unfamiliar territory.

Social engagement is key for seniors, who might find their social circle shrinking as friends and relatives move, develop serious illness or die.

Senior centers offer great resources for social activities. Something as simple as gathering with others for a regular card game can help keep the cognitive functions of the brain sharp. For some seniors, moving into a senior-living community is ideal, because it provides increased opportunities for structured activities and socialization with peers.

Through socialization, hobbies, lifelong learning, healthy eating, physical activity and challenging their brain on a daily basis, most people have the capacity to achieve healthy brain aging.

I have seen some patients reverse mild cognitive impairment simply by adopting a healthier lifestyle — so it’s never too late to encourage healthy brain aging.

Greg Jicha, M.D., Ph.D, is assistant professor of neurology in the University of Kentucky College of Medicine and UK's Sanders-Brown Center on Aging.

Saturday, February 12, 2022

A healthier diet could add years to your life, study says: more than a decade in your 20s, and eight or nine years even at age 60

Graph by University of Bergen researchers, adapted by Kentucky Health News; click on it to enlarge.

A young adult in the U.S. can add more than a decade to their life expectancy by switching from a typical Western diet to a one that includes more legumes, whole grains, and nuts and less red and processed meat. Older people would also benefit from these changes, though not as much as younger individuals. 

Researchers at the University of Bergen in Norway used data from the Global Burden of Diseases study to build a model that can instantly estimate how various dietary changes affect life expectancy. The study is published in the journal PLOS Medicine, and the model is a publicly available tool called the Food4HealthyLife Calculator.

For young adults in the U.S., the model estimates that a sustained change from a typical Western diet to the optimal diet beginning at age 20 would increase life expectancy by more than a decade for women and men. Changing at age 60 years could still increase life expectancy by eight years for women and almost nine years for men, and even 80-year-olds could gain over three years.

The study estimated gains in life expectancy from eating more or less of various types of foods, and found that the largest gains came from eating more legumes, whole grains and nuts, and less red and processed meat.

“Research until now has shown health benefits associated with separate food groups or specific diet patterns but given limited information on the health impact of other diet changes,” said Lars Fadnes, lead author of the study. “Our modeling methodology has bridged this gap.”

Monday, January 4, 2021

New federal nutrition guides, which influence school lunches, food stamps and diabetes, ignore experts' calls for less sugar, alcohol

New federal nutritional guidelines unveiled last week, which influence everything from school lunches and military rations to food stamps, ignored scientific advisers' calls to lower recommended sugar and alcohol intake. Agency officials said there wasn't enough evidence to advise stricter limits on sugar and alcohol, but emphasized that people should cut back on both. The advice has meaning for Kentucky, where nearly half the population has diabetes or pre-diabetes.

"The updated guidelines are the first to include dietary advice for infants, toddlers and pregnant women," Ryan McCrimmon reports for Politico's Weekly Agriculture. "They also have a broader theme of encouraging consumers to 'make every bite count' by choosing nutrient-rich foods and beverages, with five categories — fruits, vegetables, grains, dairy and protein — accounting for 85 percent of daily calories."

The Department of Agriculture and the Department for Health and Human Services have jointly released updated guidelines every five years since 1980. The federal government hired an independent panel of 20 doctors, nutritionists and public-health experts from major academic institutions to assist in creating the new guidelines. The Dietary Guidelines Advisory Committee "suggested the guidelines should take a harder line against added sugars, but USDA and HHS decided to keep the Obama-era advice that individuals try to not consume more than 10 percent of their calories from added sugars," Helena Bottemiller Evich reports for Politico. "The committee had recommended dropping the limit down even further to 6 percent."

The committee also "recommended in June that the guidelines should urge men to cut back on alcohol by reducing the government’s definition of 'moderate drinking' from two drinks per day to one. (At the time, the panel recommended keeping the definition of moderate drinking the same for women, at one drink per day.)," Evich reports. "Government officials ultimately decided to not adopt the stricter alcohol recommendation, which had sparked furious pushback and lobbying from the alcohol industry.

The dietary guidelines have long been a political football because of their influence over federal nutrition programs, Evich reports.